“In diabetic foot disease; diabetic peripheral neuropathy (DPN) is the primary risk factor for the development of diabetic foot ulcers.
DPN is one of the most common diabetes complications and it significantly impacts progression to the devastating outcomes of ulcerations that may lead to amputations.
Approximately 15% of all people with diabetes will be affected by a foot ulcer during their lifetime.
Diabetic foot ulcers (DFUs) often co-exist with vascular insufficiency and are the major cause of gangrene and amputation in people with diabetes. Risk of developing diabetic foot ulcers is greatly increased by reduced sensation and blood perfusion.
The reported prevalence of diabetic peripheral neuropathy ranges from 16% to as high as 66% and its prevelance is believed to increase with the duration of diabetes and poor glucose control. The definition of neuropathy is nerve disease or damage. An internationally recognized definition of DPN is “The presence of symptoms and/or signs of peripheral nerve dysfunction in people with diabetes after exclusion of other causes”.